abstract：:The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC lineage specification and commitment. Here, we show that the commitment of human and murine HSCs to the erythroid lineage is dependent upon...

journal_title：Cell stem cell

authors： Oburoglu L,Tardito S,Fritz V,de Barros SC,Merida P,Craveiro M,Mamede J,Cretenet G,Mongellaz C,An X,Klysz D,Touhami J,Boyer-Clavel M,Battini JL,Dardalhon V,Zimmermann VS,Mohandas N,Gottlieb E,Sitbon M,Kinet S,Taylo

更新日期：2014-08-07 00:00:00

abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...

journal_title：Cell stem cell

authors： Cosgun KN,Rahmig S,Mende N,Reinke S,Hauber I,Schäfer C,Petzold A,Weisbach H,Heidkamp G,Purbojo A,Cesnjevar R,Platz A,Bornhäuser M,Schmitz M,Dudziak D,Hauber J,Kirberg J,Waskow C

更新日期：2014-08-07 00:00:00

abstract：:Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs an...

journal_title：Cell stem cell

authors： Hammoud SS,Low DH,Yi C,Carrell DT,Guccione E,Cairns BR

更新日期：2014-08-07 00:00:00

abstract：:Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. Fir...

journal_title：Cell stem cell

authors： Yoon KJ,Nguyen HN,Ursini G,Zhang F,Kim NS,Wen Z,Makri G,Nauen D,Shin JH,Park Y,Chung R,Pekle E,Zhang C,Towe M,Hussaini SM,Lee Y,Rujescu D,St Clair D,Kleinman JE,Hyde TM,Krauss G,Christian KM,Rapoport JL,Wein

更新日期：2014-07-03 00:00:00

abstract：:In this issue of Cell Stem Cell, Wang et al. (2014) describe a signaling axis present in bone marrow stromal cells that suppresses inflammation and myeloid expansions. Loss of endothelial Notch signaling leads to deregulation of miR-155 expression, activation of NF-kB, and increased proinflammatory cytokine production...

journal_title：Cell stem cell

authors： Khalaj M,Park CY

更新日期：2014-07-03 00:00:00

abstract：:The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibition has been attribut...

journal_title：Cell stem cell

authors： Yeo JC,Jiang J,Tan ZY,Yim GR,Ng JH,Göke J,Kraus P,Liang H,Gonzales KA,Chong HC,Tan CP,Lim YS,Tan NS,Lufkin T,Ng HH

更新日期：2014-06-05 00:00:00

abstract：:Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cy...

journal_title：Cell stem cell

authors： Wang N

更新日期：2014-06-05 00:00:00

abstract：:In this issue of Cell Stem Cell, Palii et al. reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury. ...

journal_title：Cell stem cell

authors： Soler E,Grosveld F

更新日期：2014-05-01 00:00:00

abstract：:Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell, Kim et al. (2014) and Wu et al. (2014) extend these analyses to nonhuman primates, providing insights into dynamics of HSPC expansion and lineage commitment fo...

journal_title：Cell stem cell

authors： Dykstra B,Bystrykh LV

更新日期：2014-04-03 00:00:00

abstract：:Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...

journal_title：Cell stem cell

authors： Hobbs RM,Polo JM

更新日期：2014-03-06 00:00:00

abstract：:Cellular barcoding offers a powerful approach to characterize the growth and differentiation activity of large numbers of cotransplanted stem cells. Here, we describe a lentiviral genomic-barcoding and analysis strategy and its use to compare the clonal outputs of transplants of purified mouse and human basal mammary ...

journal_title：Cell stem cell

authors： Nguyen LV,Makarem M,Carles A,Moksa M,Kannan N,Pandoh P,Eirew P,Osako T,Kardel M,Cheung AM,Kennedy W,Tse K,Zeng T,Zhao Y,Humphries RK,Aparicio S,Eaves CJ,Hirst M

更新日期：2014-02-06 00:00:00

abstract：:The kidney's complex spatial organization and poorly defined lineage specification programs have impeded derivation of kidney progenitors from pluripotent stem cells (PSCs). Now in Cell Stem Cell, Taguchi et al. (2014) redefine the identity of embryonic kidney progenitors in vivo to obtain PSC-derived kidney progenito...

journal_title：Cell stem cell

authors： Gouon-Evans V

更新日期：2014-01-02 00:00:00

abstract：:The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...

journal_title：Cell stem cell

authors： Wu Y,Liang D,Wang Y,Bai M,Tang W,Bao S,Yan Z,Li D,Li J

更新日期：2013-12-05 00:00:00

abstract：:The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting co...

journal_title：Cell stem cell

authors： Gallagher D,Norman AA,Woodard CL,Yang G,Gauthier-Fisher A,Fujitani M,Vessey JP,Cancino GI,Sachewsky N,Woltjen K,Fatt MP,Morshead CM,Kaplan DR,Miller FD

更新日期：2013-11-07 00:00:00

abstract：:The generation of human embryonic stem cell banking networks has ensured that well-characterized and quality controlled stem cell lines are broadly accessible to researchers worldwide. Here, we provide recommendations for engaging these established networks in efforts to build similar resources for the distribution an...

journal_title：Cell stem cell

authors： Stacey GN,Crook JM,Hei D,Ludwig T

更新日期：2013-10-03 00:00:00

abstract：:DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet...

journal_title：Cell stem cell

authors： Zhang RR,Cui QY,Murai K,Lim YC,Smith ZD,Jin S,Ye P,Rosa L,Lee YK,Wu HP,Liu W,Xu ZM,Yang L,Ding YQ,Tang F,Meissner A,Ding C,Shi Y,Xu GL

更新日期：2013-08-01 00:00:00

abstract：:Inducing immune tolerance to prevent rejection is a key step toward successful engraftment of stem-cell-derived tissue in a clinical setting. Using human pluripotent stem cells to generate thymic epithelial cells (TECs) capable of supporting T cell development represents a promising approach to reach this goal; howeve...

journal_title：Cell stem cell

authors： Parent AV,Russ HA,Khan IS,LaFlam TN,Metzger TC,Anderson MS,Hebrok M

更新日期：2013-08-01 00:00:00

abstract：:Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function...

journal_title：Cell stem cell

authors： Chen H,Chen X,Zheng Y

更新日期：2013-07-03 00:00:00

abstract：:In this issue of Cell Stem Cell, Feng et al. (2013) report that the gene mutated in human CHARGE syndrome, ATP-dependent chromatin remodeling factor CHD7, contributes to the control of neurogenesis. The authors also report that exercise ameliorates these defects and suggest it as an intervention worthy of study in CHA...

journal_title：Cell stem cell

authors： Kim KH,Roberts CW

更新日期：2013-07-03 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here, we describe a new small molecule survival screen carried out using MNs from both wild-type and mutant SOD1 mouse embryonic stem cell...

journal_title：Cell stem cell

authors： Yang YM,Gupta SK,Kim KJ,Powers BE,Cerqueira A,Wainger BJ,Ngo HD,Rosowski KA,Schein PA,Ackeifi CA,Arvanites AC,Davidow LS,Woolf CJ,Rubin LL

更新日期：2013-06-06 00:00:00

abstract：:Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor...

journal_title：Cell stem cell

authors： Goldman O,Han S,Sourisseau M,Dziedzic N,Hamou W,Corneo B,D'Souza S,Sato T,Kotton DN,Bissig KD,Kalir T,Jacobs A,Evans T,Evans MJ,Gouon-Evans V

更新日期：2013-06-06 00:00:00

abstract：:Recently in Cell, Mitalipov and colleagues report an advance that has eluded scientists for over a decade-the successful derivation of embryonic stem cell lines using somatic cell nuclear transfer, or SCNT (Tachibana et al., 2013). ...

journal_title：Cell stem cell

authors： Trounson A,DeWitt ND

更新日期：2013-06-06 00:00:00

abstract：:The Adenomatous Polyposis Coli (APC) gene is mutated in the majority of colorectal cancers (CRCs). Loss of APC leads to constitutively active WNT signaling, hyperproliferation, and tumorigenesis. Identification of pathways that facilitate tumorigenesis after APC loss is important for therapeutic development. Here, we ...

journal_title：Cell stem cell

authors： Myant KB,Cammareri P,McGhee EJ,Ridgway RA,Huels DJ,Cordero JB,Schwitalla S,Kalna G,Ogg EL,Athineos D,Timpson P,Vidal M,Murray GI,Greten FR,Anderson KI,Sansom OJ

更新日期：2013-06-06 00:00:00

abstract：:Realizing the therapeutic potential of both stem cell and genomics research requires harnessing the respective strengths of academic, biotechnology, and pharmaceutical sectors, supported by policies and legal incentives for multisectorial collaboration. Here, we discuss issues facing these fields and lessons from the ...

journal_title：Cell stem cell

authors： Mathews DJ,Cook-Deegan R,Bubela T

更新日期：2013-05-02 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide techniques includin...

journal_title：Cell stem cell

authors： Ramos AD,Diaz A,Nellore A,Delgado RN,Park KY,Gonzales-Roybal G,Oldham MC,Song JS,Lim DA

更新日期：2013-05-02 00:00:00

abstract：:The cellular identity of niche cells that regulate hematopoietic stem cell (HSC) self-renewal and differentiation has been debated for several years. Two recent studies in Nature (Ding and Morrison, 2013; Greenbaum et al., 2013) have shed light into the bone marrow stromal subsets making CXCL12, a chemokine critical f...

journal_title：Cell stem cell

authors： Hanoun M,Frenette PS

更新日期：2013-04-04 00:00:00

abstract：:The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. ...

journal_title：Cell stem cell

authors： Haimes E,Skene L,Ballantyne AJ,Caulfield T,Goldstein LS,Hyun I,Kimmelman J,Robert JS,Roxland BE,Scott CT,Solbakk JH,Sugarman J,Taylor PL,Testa G,ISSCR.

更新日期：2013-03-07 00:00:00

abstract：:Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part, through the alternative splicing of self-renewal and survival genes. To elucidate splice-isoform regulators of human BC LSC maintena...

journal_title：Cell stem cell

authors： Goff DJ,Court Recart A,Sadarangani A,Chun HJ,Barrett CL,Krajewska M,Leu H,Low-Marchelli J,Ma W,Shih AY,Wei J,Zhai D,Geron I,Pu M,Bao L,Chuang R,Balaian L,Gotlib J,Minden M,Martinelli G,Rusert J,Dao KH,Shazand

更新日期：2013-03-07 00:00:00

abstract：:Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonica...

journal_title：Cell stem cell

authors： Turner SA,Bracken AP

更新日期：2013-02-07 00:00:00

abstract：:Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy for combating many types of cancer and viral infection. However, exhaustion of antigen-specific T cells represents a major challenge to this type of approach. In an effort to overcome this problem, we reprogrammed clonally ...

journal_title：Cell stem cell

authors： Nishimura T,Kaneko S,Kawana-Tachikawa A,Tajima Y,Goto H,Zhu D,Nakayama-Hosoya K,Iriguchi S,Uemura Y,Shimizu T,Takayama N,Yamada D,Nishimura K,Ohtaka M,Watanabe N,Takahashi S,Iwamoto A,Koseki H,Nakanishi M,Eto K,Na

更新日期：2013-01-03 00:00:00

abstract：:Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs. ...

journal_title：Cell stem cell

authors： Warr MR,Passegué E

更新日期：2013-01-03 00:00:00

abstract：:The discovery that phenotypic diversity among differentiated cells results from epigenetic and not genetic differences, and can be reset to restore pluripotency, promises revolutionary advances in medicine. I discuss how this and related seminal discoveries have brought us to an exciting future. ...

journal_title：Cell stem cell

authors： Surani MA

更新日期：2012-12-07 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) can either suppress or promote tumors. We found previously that incubation of human bone marrow MSCs (hMSCs) with TNF-α upregulated multiple genes including TRAIL, which has cancer apoptotic activity. Here, we show that weekly infusions into mice of hMSCs preactivated with TNF-α i...

journal_title：Cell stem cell

authors： Lee RH,Yoon N,Reneau JC,Prockop DJ

更新日期：2012-12-07 00:00:00

abstract：:In the mouse embryo, the aorta-gonad-mesonephros (AGM) region is considered to be the sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we report that, in parallel to the AGM region, the E10.5-E11.5 mouse head harbors bona fide HSCs, as defined by long-term, high-level, multilineage r...

journal_title：Cell stem cell

authors： Li Z,Lan Y,He W,Chen D,Wang J,Zhou F,Wang Y,Sun H,Chen X,Xu C,Li S,Pang Y,Zhang G,Yang L,Zhu L,Fan M,Shang A,Ju Z,Luo L,Ding Y,Guo W,Yuan W,Yang X,Liu B

更新日期：2012-11-02 00:00:00

abstract：:In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal...

journal_title：Cell stem cell

authors： Troy A,Cadwallader AB,Fedorov Y,Tyner K,Tanaka KK,Olwin BB

更新日期：2012-10-05 00:00:00

abstract：:The transcription factors Tcf3 and Nanog regulate many genes in embryonic stem cells, but according to two reports in this issue of Cell Stem Cell (Festuccia et al., 2012, Martello et al., 2012), only one, Esrrb, encoding an orphan nuclear hormone receptor, truly matters in the maintenance of self-renewal. ...

journal_title：Cell stem cell

authors： Zwaka TP

更新日期：2012-10-05 00:00:00

abstract：:Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...

journal_title：Cell stem cell

authors： Chu SH,Heiser D,Li L,Kaplan I,Collector M,Huso D,Sharkis SJ,Civin C,Small D

更新日期：2012-09-07 00:00:00

abstract：VIDEO ABSTRACT:Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical...

journal_title：Cell stem cell

authors： Wang J,Gallagher D,DeVito LM,Cancino GI,Tsui D,He L,Keller GM,Frankland PW,Kaplan DR,Miller FD

更新日期：2012-07-06 00:00:00

abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

journal_title：Cell stem cell

authors： Fuentealba LC,Obernier K,Alvarez-Buylla A

更新日期：2012-06-14 00:00:00

abstract：:Stroma is a largely understudied component of all organs that contributes to stem cell niches. Studies to define stromal components in the bone marrow have led to some unexpected findings that prompt further research. ...

journal_title：Cell stem cell

authors： Scadden DT

更新日期：2012-06-14 00:00:00